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It was only later that pharmaceutical companies started developing new SARMs which were distinctly different from steroids in crucial aspects. In terms of pharmacokinetics, a SARM has a fixed molecular weight and in the presence of its antagonist molecule acts as a water-soluble drug. The SARMs used in humans today have an entirely different composition of steroids and in general a totally different molecular weight to the analogues they were derived from. The first SARMs to have been introduced into human clinical use were the synthetic form of stanozolol, which has a molecular weight of 8.7 kilogram per kilogram (Kg/kg) and an IC 50 of 562 microg/kg. It was soon followed by the artificial form of stanozolol, which has a molecular weight of 7.7 Kg/kg and an IC 50 of 511 microg/kg. This form of stanozolol was approved for the treatment of acne in 1981, and it was followed by a series of SARMs based on the natural steroids as well as synthetic SARMs. The SARMs developed since the 1970s have undergone a number of changes in composition. Most of them were created by adding a number of non-steroidal steroids along with their synthetic counterparts. These non-steroidal steroid components have a variety of properties such as anti-inflammatory, neuroprotective, immunosuppressant, anti-oxidant, antiproliferative, anti-inflammatory anti-allergic, analgesic, and antipsychotic properties. Another important factor in SARMs' pharmacokinetics in humans is whether they are taken at recommended doses or at high doses during an acute episode. As in pharmaceuticals, one of the most important factors in prescription drugs is the maximum therapeutic dose. The average human dose in medicine ranges from 8 to 90 milligrams, and the FDA classifies it as an "effective therapeutic dose." In the case of SARMs, the maximum therapeutic dose of the products available to the public is usually 100 mg per day. The therapeutic dose of SARMs is often not disclosed in pharmaceutical claims or on labeling unless an effective therapeutic dose is specifically specified by a manufacturer. However, it is clear that high therapeutic doses are achieved either through the use of a non-steroidal SARM and a non-SARM mixture, or via the administration of a SARM. (This distinction has been widely accepted in the medical community, but there is concern expressed by manufacturers that the FDA regulation of SARMs is not being observed).  Similar articles: